The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes
نویسندگان
چکیده
منابع مشابه
The Hedgehog Receptor Patched Is Involved in Cholesterol Transport
BACKGROUND Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by th...
متن کاملIntracellular cholesterol transport.
Intracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis. Many aspects of cholesterol metabolism are well-known, including its synthesis in the endoplasmic reticulum, its extracellular transport in plasma lipoproteins, its uptake by the low-density lipoprotein receptor, and its regulation of SREBP and LXR transcription factors. These fundamental pathways i...
متن کاملIntracellular cholesterol transport.
correct intracellular distribution of cholesterol among cellular membranes is essential for many biological functions of mammalian cells, including signal transduction and membrane traffic. Intracellular trafficking plays a major role in the proper disposition of internalized cholesterol and in the regulation of cholesterol efflux. Despite the importance of the transport and distribution of cho...
متن کاملNPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.
Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins, polytopic membrane-bound Niemann-Pick C1 (NPC1) and soluble Niemann-Pick C2 (NPC2). The reason for this dual requirement is unknown. Previously, we showed that the soluble luminal N-terminal domain (NTD) of NPC1 (amino acids 25-264) binds cholesterol. This NTD is designated NPC1(NTD). We and others showed ...
متن کاملDrug targeting to lysosomes.
1982). It is not clear how the rate of entry into lysosomes themselves is affected, but it may be retarded. The situation is even more obscure in the case of entry into lysosomes by autophagy. There are some indications of abnormalities in endogenous protein breakdown, and in perhaps of the lysosomal component thereof, in I-cell disease (Cockle & Dean, 1984). Similarly, Sameshima et al. (1981) ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.06.012